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Formula & Ingredients

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Formula & Ingredients

Overview

Cosmoperine is mixed with our naturally-derived sleep formula on the Sleep ZPatch. It's prepared from piperine (found in black pepper and long pepper) by a patented proprietary process. Cosmoperine used to increase the absorption of drugs and nutrients through the skin.
 

Physiological Effects

There are no reported cases of sleep enhancement with cosmoperine, the compound is merely used to increase skin absorption of other compounds.
 

How It Works

The mechanism of action is currently unclear but possible explanations include increasing cell membrane fluidity allowing compounds to pass through or making the compound more likely to attach the cell membrane which would facilitate passage into the cell.

Dosing and Administration

Cosmoperine can be used in a patch to facilitate absorption through skin. No toxicity reports have been noted with doses at or below 50mg/kg bodyweight.

Side Effects

In a small study (46 people) there were no side effects reported.

Safety

when used in a patch to facilitate absorption there does not appear to be any safety risks at this time.  Consult with your doctor if having any issues while using cosmoperine.
 

Source:

www.cosmoperine.com
2 Badmaev, V; Majeed, M; Skin and Its Role In Providing Nourishment To the Body – Pungent Principles of Black Pepper, Alkaloid Piperine, and Tetrahydropiperine (THP) as Enhancers of Nutrient and Drug Bioavailability.  Cosemtic Science Technology 2004.

Overview

Passionflower has been shown to reduce anxiety in patients taking the oral supplement prior to outpatient surgical procedures. Passionflower supplementation in tea has shown short-term subjective sleep benefits for healthy adults.

Origin

Passionflower, Passiflora incarnata, is a plant found native to the southern United States, Central and South America. Native American and Aztec cultures have used the plant for centuries citing its calming and healing properties.

Physiological Effects

Passionflower contains sleep-promoting flavonoids that have affinity for central benzodiazepine and gamma-aminobutyric acid (GABA) receptors. Increased GABA activity creates a calming effect on the central nervous system.

Dosing and Administration

Standard supplement doses come in 350-1,050 mg taken 2 to 3 times daily for a total dose of 1-3g daily.

Side Effects

Side effects are rare but include drowsiness, sedation, nausea, vomiting, and dizziness.

Safety

No studies have examined the effects of Passionflower in children. Consultation with a physician is recommended. Do not take Passionflower while pregnant or breastfeeding. Passionflower may interact with the following mediations: Sedatives, Antiplatelet/Anticoagulants, and monoamine oxidase inhibitors.

 

Sources:

Movafegh A, et al. Preoperative oral Passiflora incarnate reduces anxiety in ambulatory surgery patients: a double-blind, placebo-controlled study. Anesth Analg. 2008 Jun;106(6):1728-32.

NganA, Conduit R. A double-bling, placebo-controlled investigation of the effects of Passiflora incarnate (passionflower) herbal tea on subjective sleep quality. Phytother Res. 2011 Aug;25(8):1153-9.

Spielholz C. Passion Flowers: Exciting Results when Traditional Knowledge is Confirmed by Modern Science. Nutraceutical Medical Research Industry News. Vol 2, Issue 2, May 2009.

Loli F, Sato CM, et al. Possible involvement of GABAa-benzodiazepine receptor in the anxiolytic-like effect oinduced by Passiflora actinia extracts in mice. J Ethnopharmacol. 2007;111:308-14.

Bystritsky A. Complementary and alternative treatments for anxiety symptoms and disorders: Herbs and medications. UpToDate. Jan 2018.

GABA is one of your body’s primary neurotransmitters, and acts to calm your central nervous system. Research has shown the GABA supplement to be effective in natural treatment for depression, anxiety, insomnia, and addiction.

Overview

5-HTP may have a positive effect on sleep, mood, anxiety, appetite, and pain sensation. When taken with gamma aminobutyric acid (GABA), 5-HTP might help people fall asleep faster, decrease sleep latency, increase duration of sleep, and improve the quality of sleep.


Origin

5-HTP can be produced as a supplement from the seeds of an African plan called Griffonia simplicifolia.


Physiological Effects

Tryptophan, an essential amino acid obtained through food, is converted by the body to 5-HTP via the enzyme tryptophan hydroxylase. 5-HTP is then converted into serotonin, a prominent central nervous system neurotransmitter that regulates mood and behavior.


Dosing and Administration

The supplement is part of our naturally-derived formula on the Sleep ZPatch, and is absorbed through the skin. 


Side Effects

No significant side effects toxicity have been reported with doses at or below 50mg/kg bodyweight. The Sleep ZPatch is well below this threshold.


Safety

Consult with your physician if taking any of the following classes of medications as 5-HTP may interact adversely; Antidepressants, Carbidopa, Tramadol, Dextromethorphan, Meperidine, & Triptans.3

 

Source:

Ehrlich S, 5-Hydroxytryptophan (5-HTP), University of Maryland Medical Center Medical Reference Guide, https://www.umm.edu/health/medical/altmed/supplement/5hydroxytryptophan-5htp, January 2017.

Shell W, et al. A randomized, placebo-controlled trial of an amino acid preparation on timing and quality of sleep. Am J Ther. (2010).

Birdsall TC. 5-Hydroxytryptophan: a clinically-effective serotonin precursor. Altern Med Rev. 1998;3(4):271-280.

Breus M, Better Sleep with 5-HTP, Psychology Today. October 12, 2017.

Turner EH, Loftis JM, Blackwell AD. Serotonin a la caret: supplementation with the serotonin precursor 5-hydroxytryptophan. Pharmacol Ther. (2006).

Skullcap is the name of a flowering perennial plant from the mint family, Lamiaceae. Skullcap is known to help prevent certain cancers, reduce anxiety, soothe the nervous system, treat diabetes, aid in weight loss, lower inflammation, balance hormones, and regulate sleep.

L-theanine is known to promote relaxation, reduce stress, and improve sleep, as well as boost concentration and alertness. It's a naturally occurring amino acid that appears to alter levels of various neurotransmitters, producing a calming effect.

Magnesium is the fourth most abundant mineral in the human body. Every cell in your body needs it to function. One of magnesium's main roles is acting as a cofactor or "helper molecule" in the biochemical reactions continuously performed by enzymes. It helps to calm nerves and reduce anxiety and is typically used to treat insomnia and help you fall asleep.

Valerian is widely used and respected by the general population and physicians for its sedative effects and anti-anxiety capabilities. Studies show that valerian reduces the time it takes to fall asleep and improves the quality of sleep.

Hops have traditionally been used to help with sleep issues and several studies have analyzed its effectiveness as a sleep aid. In combination with valerian, hops can help relax stressed muscles, ease stiff joints and prevent spasms and twitching.

Overview

Melatonin has the ability to reduce sleep onset time and increase sleep duration. Melatonin is a naturally occurring hormone that plays of a role in initiating and maintaining sleep and control of our 24-hour rhythms.

Origin

Melatonin is naturally occurring, produced and secreted by the pineal gland and acts on
receptors in the hypothalamus. The pineal gland is stimulated to release melatonin by the evening hours and a dark environment.

Physiological Effects

There is a melatonin secretion surge in the evening thought to be associated with the
beginning of sleep propensity. The primary physiological function is to convey information concerning the daily cycle of light and darkness to body structures. This helps us respond to changes in the light period and organizes seasonal and circadian rhythms. 3

Dosing and Administration

Physiologic doses range from 0.1 to 0.3 mg for sleep and 0.3 to 0.5 mg for phase
shifting. 

Safety

People who are pregnant, breastfeeding or have a history of hypertension, diabetes,
depression, autoimmune disease, and/or seizure disorders should consult with a
physician prior to the use of melatonin. Prolonged use of high doses may desensitize the melatonin receptors in the brain.

We define "Naturally Occurring Ingredients" as ingredients that are found either in nature through plants, herbs, or minerals, or are produced or found in/by the body through it's regular process' as physical or neurological process'.  The current ingredients we consider to be naturally occurring include but are not limited to:  Magnesium, Valerian Root, Hops, L-Theanine, Melatonin, Passion Flower, GABA, 5HTP, Skullcap, and Cosmoperine. 

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